In Vitro Pharmacology
In vitro pharmacology assessments deliver key insights into Mechanisms of Action (MOA), biological activity, and potency, driving a deeper understanding of the safety and efficacy of new therapeutic candidates.
Our team of scientific experts have created sophisticated models and tools that are highly adaptable to individual research goals and provide robust and reliable data. Our approach goes beyond merely executing assays under customer direction; we actively collaborate with our customers, providing strategic insights and advise upon on alternative approaches to maximize the project value and outcomes.
We have extensive, demonstrated experience working with multiple customers across various products, establishing ourselves as the go-to supplier for outsourced support to conduct in vitro pharmacology studies.
Translational Expertise
Innovative Techniques and Technologies
Advanced Models and Tools
Inducible Expression (IndEx-2)
We excel at linking complex methodologies developed during early discovery phases to the in vitro pharmacology stage. The data generated supports longer-term assay development, contributing to formal characterisation stages and the development of methods for GMP lot release. This continuity ensures that our customers have a cohesive and comprehensive development pathway, from early discovery through to clinical and commercial stages.
We excel at integrating advanced instrumentation with high-content methodologies to investigate cellular processes in depth. Our capabilities extend beyond traditional assays, employing kinetic measurements and immune cell activation assessments through endpoints such as cytokine release and the modulation of key cellular factors. These innovative techniques support the development of more refined assays, contributing to enhanced characterisation and the establishment of robust methods for clinical and commercial applications. This integration ensures a seamless progression from cellular interrogation to assay development and beyond, aligning with the needs of our customers throughout the development process.
Our models and tools are at the forefront of in vitro pharmacology. We have developed streamlined processes utilising primary cells from both healthy donors and patients. We can recall donors to ensure ongoing consistency, and our capabilities include collecting individual cell subtypes, as well as generating, inducing, and deriving various subtypes of all immune cell classes. This flexibility allows us to create highly relevant models tailored to specific therapeutic contexts.
Our IndEx-2 assay system provides a powerful in vitro model for assessing how antigen expression levels impact the efficacy and safety of targeted therapeutics. This flexible platform allows for the controlled expression of one or two antigens, offering a unique ability to estimate the antigen expression thresholds necessary for therapeutic activation. By supporting detailed evaluation throughout the development process, IndEx-2 contributes to the refinement of therapeutic strategies, ensuring a smooth transition from early research to clinical applications.
Propel drug discovery breakthroughs with RoukenBio
Difficulty doesn’t deter us; it inspires us. Give us a problem, and we’ll find your solution. Our versatile specialists embrace every obstacle as an opportunity to showcase our innovative thinking and problem-solving prowess.
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