Cell Lines

Cell lines are developed in a CHO-K1 background and allow inducible expression of the gene(s) of interest upon the application of the inducer. 

Single-inducible cell lines:

• B7H3 (CD276)
• BCMA
• CD19
• CD22
• cMET
• EGFR
• EpCAM (Tacstd1)
• FOLR1
• HER2
• PDL1 (CD274)
• PMSA (FOLH1)

Dual-inducible cell lines:

• CD19/CD22

Inducible cell lines in different cancer backgrounds:

• A549 - FOLR1
• HCT116 - B7H4

New cell lines are continuously under development so do not hesitate to contact us for more information.

Reporter cell lines are produced and tested in-house:

• Jurkat NFAT: A Jurkat T-cell line expressing NFAT, designed to monitor T-cell receptor (TCR) activation.
• Jurkat PD-1/CHO PD-L1 reporter assay: A co-culture of Jurkat PD-1 and CHO PD-L1/TCR activator cells, to assess PD1/PDL1 targeting molecules.
• Jurkat FcγRIIIa (CD16) V176 NFAT: A Jurkat cell line expressing the FcγRIIIa (CD16) V176 receptor, used to assess CD16 engagement (ADCC).
• Jurkat FcγRIIIa (CD16) F176 NFAT: A Jurkat cell line expressing the FcγRIIIa (CD16) F176 receptor, used to assess CD16 engagement (ADCC).
• Jurkat FcγRIIa (CD32a) H167 NFAT: A Jurkat cell line with the FcγRIIa (CD32a) H167 variant, use to assess CD16 engagement (ADCP).
• Jurkat FcγRI (CD64) NFAT: A Jurkat cell line expressing FcγRI (CD64), designed to monitor Fc receptor signalling (ADCP).
• HEK293 SRE: A HEK293 cell line engineered to study multiple receptor signalling pathways by monitoring ERK1/2 signalling activation.
• HEK293 NFκB: A HEK293 cell line used to study various receptor pathways (e.g. TNFR1 or TLRs) via NFκB activation.
• Jurkat NKG2D reporter assay: A Jurkat cell line expressing the NKG2D allowing the assessment of NKG2D signalling after MICA/B engagement.
• HEK293 TSLPR/IL-7R STAT5: A HEK293 cell line co-expressing TSLPR and IL-7R, designed to monitor STAT5 signalling in response to receptor activation.
• HEK293 STAT6: A HEK293 cell line engineered to study IL-4/IL-13 receptor signalling through STAT6 activation.
• CHO-K1 TrkB NFAT: A CHO cell line expressing the TrkB receptor, used to monitor TrkB signalling pathways via NFAT activation.
• CHO-K1 Tie Reporter assay: A CHO cell line expressing the Tie2 receptor, designed to monitor Tie2 signalling through an undisclosed pathway.

New cell lines are continuously under development so do not hesitate to contact us for more information.