We specialise in creating cell lines for all stages of therapeutic development; cell-based bioassays for screening, selection, functional assessments, potency assays and lot release. Our expert team employ a range of molecular tools to create custom genetically engineered cell lines to specification and fit for the intended application.
IndEx-2 cell lines
Reporter cell lines
Single-inducible cell line specification sheets:
B7-H3 (CD276)
BCMA
CD19
B7H3 (CD276) is an immune checkpoint molecule that is selectively overexpressed in tumour tissues and immune cells. It is associated with tumour proliferation, metastasis, and therapeutic resistance. This cell line has been developed in a CHO-K1 background and allows inducible expression of B7H3.
Inducible Gene: B7-H3 | Species: Human | UniProt: Q5ZPR3
Histograms and quantification of B7-H3 induction at 0-100 μM small molecule inducer
Cells were then stained with a labelled antibody and expression levels quantified using a bead-based quantification kit. Specific induction conditions should be further defined by the user. Cell line suitable for research and development use only.
Reporter cell lines are produced and tested in-house:
New cell lines are continuously under development so do not hesitate to contact us for more information.
Jurkat NFAT
Jurkat PD-1/CHO PD-L1 reporter assay
A Jurkat T-cell line expressing NFAT, designed to monitor T-cell receptor (TCR) activation.
Discover the latest dual inducible IndEx-2 data and dive into two in-depth CAR-T case studies in our exclusive technical slide deck.
Access the slide deck