We specialise in creating cell lines for all stages of therapeutic development; cell-based bioassays for screening, selection, functional assessments, potency assays and lot release. Our expert team employ a range of molecular tools to create custom genetically engineered cell lines to specification and fit for the intended application.
Enquire about available IndEx-2 cell linesIndEx-2 cell lines
Reporter cell lines
B7-H3
BCMA
CD19
CLDN3
CLDN18.2
cMET
DLL3
EGFR
EpCAM
HER2
PSMA
TROP2
Gene name: CD276
B7-H3 is a type I transmembrane protein and a member of the B7 family of immune checkpoint molecules. It plays a complex role in immune regulation, generally thought to inhibit T-cell activation, although some studies suggest a co-stimulatory role under certain conditions. The CD276 gene is frequently overexpressed in a wide range of solid tumours, including prostate, breast, non-small cell lung cancer (NSCLC), and glioblastoma, while its expression is limited in normal tissues. This tumour-restricted expression makes B7-H3 an attractive target for antibody-drug conjugates (ADCs), CAR-T cells, and other immunotherapeutic strategies.
CHO-K1 IndB7-H3
Cell Line background: CHO-K1 | Inducible Gene: B7-H3 | Species: Human | UniProt: Q5ZPR3
Histograms and quantification of B7-H3 induction at 0-100 μM small molecule inducer
Cells were then stained with a labelled antibody and expression levels quantified using a bead-based quantification kit. Specific induction conditions should be further defined by the user. Cell line suitable for research and development use only.
Reporter cell lines are produced and tested in-house:
New cell lines are continuously under development so do not hesitate to contact us for more information.
Jurkat NFAT
Jurkat PD-1/CHO PD-L1 reporter assay
A Jurkat T-cell line expressing NFAT, designed to monitor T-cell receptor (TCR) activation.
Discover the latest dual inducible IndEx-2 data and dive into two in-depth CAR-T case studies in our exclusive technical slide deck.
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